Comprehensive Prostate Formula is a complete nutritional program for supporting prostate health with herbs, vitamins, mineral, and other nutrients known to benefit the prostate gland.
Herbs
Saw palmetto extract- The Saw palmetto in Comprehensive Prostate Formula is standardized to contain 85 to 90% fatty acids, which are the active ingredients in the Saw palmetto berry that promote prostate health. Three tablets supplies 320 mg, the daily dose used for prostate therapy in clinical studies.
Pygeum extract- Pygeum is an evergreen tree native to the high plateaus of southern Africa. Pygeum bark contains phytosterols, beta sitterol and other sitosterols, natiral sterols that have been shown to normalize the prostate. Clinical trials establish 100 mg per day as a highly effective dose of Pygeum extract, especially in combination with Nettle root.
Nettle root extract- Nettle, also know as "Stinging Nettle," grows wild in forests and fields throughout North America and Europe. Nettle root has been researched in European studies and shown to benefit the prostate and urinary tract. While the specific active ingredients in Nettle for prostate support have not been positively identified, Nettle's effect on the prostate may stem from its content of polysaccharides and isolection. 300 mg per day is a clinically effective dose of Nettle root extract.
Amino acids - The combination of L-alanine, glutamic acid and glycine was first used for prostate support in 1958. Two medical doctors administered the amino acids to allergy patients who reported improvement in urinary function.
Lycopene - Tomatoes are rich in carotenes, natural pigments responsible for colors in fruits and vegetables. Lycopene gives the tomato fruit its red color. Recent research suggests that lycopene may help reduce the risk of prostate cancer. (These findings, however, are strictly preliminary and await confirmation through further research.)
Minerals - The human prostate contains a high concentration of zinc, which is known to be a key mineral for prostate health. Selenium, an essential trace mineral, may play a role in cancer risk reduction. Recent work by Harvard University researchers showed that men with the highest levels of selenium were less likely to develop prostate cancer than those with the lowest selenium levels. Copper is added to balance zinc. When supplementing with zinc, it is advised to take a small amount of additional copper to prevent copper deficiency.
Vitamins - Vitamin E is added as an antioxidant and is support for the reproductive system. Vitamin B6 may benefit the prostate by reducing excess levels of the hormone prolactin.
Benefits
Helps maintain a healthy prostate gland
Supports normal urinary function
Clinical Studies Saw Palmetto Extract
Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted over the last fifteen years suggest Saw palmetto extract can produce major improvements in prostate-related urinary function. In clinical studies, Saw palmetto extract has produced measurable improvements in urinary functions and prostate size. Quality of life scores have also improved.
The results with Saw palmetto extract have been duplicated in open trials and controlled, double-blind studies.
For example, in a large open trial, 505 men took 320 mg of Saw palmetto extract daily for three months. The results were evaluated with various measurements such as the International Prostate Symptom Score, the quality of life score, urinary flow rates, residual urinary volume, and prostate size. After 45 days these parameters improved significantly. After 90 days of treatment nearly ninety percent of both the doctors and patients regarded Saw palmetto extract as an effective therapy for the prostate.
The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an enzyme that controls conversion of testosterone to DHT.
Experimental evidence suggests Saw palmetto extract blocks the binding of DHT to prostate cells. The fatty acids and sterols in Saw palmetto are believed to be responsible for these actions. These include oleic acid, lauric acid, campasterol, stigmasterol, beta sitosterol and others. Clinical studies have used extracts containing 85 to 90% fatty acids and sterols.
Pygeum Extract
Like Saw palmetto, Pygeum contains natural sterols and fatty acids. Although the mechanisms for its effect have not been clearly established, animal experiments suggest Pygeum may work by inhibiting prostate cell proliferation and reducing inflammation.
In several European trials, Pygeum has successfully improved urinary function. In a large double-blind, placebo-controlled study, 263 men were given 100 mg of Pygeum extract a day for 60 days. Urination improved in 66 percent of the men taking Pygeum, compared with 31 percent on placebo, based on subjective and objective tests.
Nettle Root Extract
Nettles are approved by the German Commission E as effective for relieving inflammation in the urinary tract. As far back as 1950, German investigators have observed favorable effects on the prostate with the used of Nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals.
In a recent double blind study published in the journal of Clinical Therapeutics, 134 men took a combination of Nettle root extract and Pygeum extract over a period of 56 days. Urination was significantly improved.
L-Alanine, Glutamic Acid and Glycine
As noted above, Drs. Feinblatt and Gant discovered that a combination of the amino acids L-alanine, glutamic acid and glycine has a positive effect on prostate-related urinary function. A controlled study of 45 men was conducted to follow up on these initial observations. The majority of subjects experienced complete or partial relief in urinary complaints such as nighttime urination and urgency.
Comprehensive Prostate Formula by Doctor's Best Comprehensive Prostate Formula is a complete nutritional package for the prostate gland. The formula contains the leading herbs, amino acids, minerals and vitamins which are known to benefit prostate health and function. The suggested daily serving of three tablets supplies effective amounts of the key therapeutic ingredients - the herbs and amino acids - as demonstrated in clinical studies. The vitamins, minerals and lycopene are included as supportive ingredients for prostate health maintenance.
The Saw Palmetto extract in this product is standardized to provide 290 mg of active ingredients (fatty acids and sterols) per the suggested daily dose of three tablets, which equals the amount of these therapeutic ingredients in the extracts used in clinical studies.
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Scientific References
Braeckman, J. The extract of Serenoa repens in the treatment of benign prostatic hyperplasia: a multicenter open study, Current Therapeutic Research 1994: 55(7): 776-85.
Lawrence Review of Natural Products. Pygeum. Jan 1998. Facts and Comparison, St. Louis, MO.
Combined extracts of Urtica diolca and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses Clinical Therapeutics 1993; 15(6): 1011-19.
Wagner H., Willer F., Samtleben R., Boos G. Search for the antiprostatic principle of stinging nettle (Urtica diolca) roots Phytomedicine 1994; 1: 213-224.
Feinblatt, H.M., Grant J.D. Palliative treatment of benign prostatic hypertrophy. Journal of the Maine Medical Association, March 1958: 99-124.
Giovanni E., et al. Intake of carotenoids and retinol in relation to risk of prostate cancer. Journal of the National Cancer Institute 1995; 87(23): 1767-76.
Wallace A.M., Grant J.K. Effect of zinc on androgen metabolism in the human hyperplastic prostate. Biochemical Society Transactions 1975; 3(3): 540-42.
Dabmaev V., Majeed M., Passwater R. Selenium: A quest for better understanding. Alternative Therapies 1996; 2(4): 59-67.
Fouhad M.T. Selenium and cancer, chromium and diabetes: two trace elements that have merits as dietary supplements in human nutrition. Journal of Applied Nutrition 1979; 31(1&2): 14-17.
Tasca A., et al. Treatment of obstructive symptomatology caused by prostatic adenoma with an extract of Serenoa repens. Double-blind clinical study vs. placebo. Minerva Urologica e Nefrologica 1985; 37: 87-91.
Champault G., Bonnard A.M., Cauquil J., Patel J.C. Medical treatment of prostatic ademona. A controlled test of PA 109 vs. placebo in 110 patients. Ann. Urol. 1984; 18(6): 407-410.
Crimi A., Russo A. The use of Serenoa repens extract in the treatment of functional disturbances caused by prostate hypertrophy. Med. Praxis 1983; 4: 47-51.
Sultan C., et. al. Inhibition of adrogen metabolism and binding of liposterolic extract of Serenoa repens B in human foreskin fibroblasts. J. Steroid Biochem. 1984; 20(1): 515-519.
Weissner H., et al. Effects of the Sabal serrulata extract IDS 9 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasia. The Prostate 1996; 28: 300-06.
Yablonsky F., Nicolas V., Riffaud J.P., Bellamy F. Antiproliferative effect of Pygeum africanum on rat prostatic fibroblasts. Journal of Urology 1997; 157: 2381-87.
Marconi M., et al. Anti-inflammatory action of Pygeum extract in the rat. Farmaci. & Terapia. 1986; 3: 135.
Barlet A., et al. Efficacy of Pygeum africanum extract in the treatment of micturational disorders due to benign prostatic hyperplasia. Evaluation of objective and subjective parameters. A multi-center, randomized, double-blind trial. Wien. Klin. Wocheschr. 1990; 22: 667-73.
The Complete German Commission e Monographs. 1998, Blumenthal, M., ed., (p. 216) Austin, TX: American Botanical Council.
Damrau, F. Benign prostatic hypertophy: amino acid therapy for symptomatic relief. American Journal of Geriatrics 1962; 10: 426-30.
Comprehensive Prostate Formula by Doctor's Best Comprehensive Prostate Formula is a complete nutritional package for the prostate gland. The formula contains the leading herbs, amino acids, minerals and vitamins which are known to benefit prostate health and function. The suggested daily serving of three tablets supplies effective amounts of the key therapeutic ingredients - the herbs and amino acids - as demonstrated in clinical studies. The vitamins, minerals and lycopene are included as supportive ingredients for prostate health maintenance.
The Saw Palmetto extract in this product is standardized to provide 290 mg of active ingredients (fatty acids and sterols) per the suggested daily dose of three tablets, which equals the amount of these therapeutic ingredients in the extracts used in clinical studies.
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